1997;6(8):617-623. View abstract. Am J Clin Nutr 2004;80:1508-20. JAMA Ophthalmol 2017;135(11):1259-1266. Int J Food Sci Nutr 2016;67(7):744-53. 2013;91(1):6-11. Breast Cancer Res.Treat. Select a condition to view a list of vitamins. View abstract. Several studies 1999;19(6):491-495. 2009;102(2):186-190. View abstract. Am.J.Clin.Nutr. Am J Clin Nutr 1998;68:82-9. Feng L, Nie K, Jiang H, Fan W. Effects of lutein supplementation in age-related macular degeneration. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. 2012;17(3):3202-3242. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. 8-15-2012;92(10):2043-2049. Vision Res. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Seddon JM, Ajani UA, Sperduto RD, et al. JAMA 2013;309(19):2005-2015. View abstract. View abstract. Effect of the main dietary antioxidants (carotenoids, gamma-tocopherol, polyphenols, and vitamin C) on alpha-tocopherol absorption. View abstract. JAMA. View abstract. Spread supplemented with moderate doses of vitamin E and carotenoids reduces lipid peroxidation in healthy, nonsmoking adults. J.Matern.Fetal Neonatal Med. 2007;42(5):720-726. Berendschot, T. T., Broekmans, W. M., Klopping-Ketelaars, I. View abstract. Eur.J.Clin.Nutr. Since the plant View abstract. View abstract. Morganti, P., Fabrizi, G., and Bruno, C. Protective effects of oral antioxidants on skin and eye function. View abstract. Berson EL, Rosner B, Sandberg MA, et al. Vitamin A and carotenoids and the risk of Parkinson's disease: a systematic review and meta-analysis. Berendschot, T. T., Goldbohm, R. A., Klopping, W. A., van de, Kraats J., van Norel, J., and van Norren, D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Schweiggert, R. M., Mezger, D., Schimpf, F., Steingass, C. B., and Carle, R. Influence of chromoplast morphology on carotenoid bioaccessibility of carrot, mango, papaya, and tomato. Bartlett, H. E. and Eperjesi, F. A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. In addition to being found within thepigments of oureyes, carotenoids are also present within the skin. Product Details: and antioxidant-rich lutein, which protects against blue-light-induced skin aging. Invest Ophthalmol Vis Sci 1995;36:276-88. Thyagarajan, B., Meyer, A., Smith, L. J., Beckett, W. S., Williams, O. D., Gross, M. D., and Jacobs, D. R., Jr. Serum carotenoid concentrations predict lung function evolution in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Reboul E, Thap S, Perrot E, et al. Thomson, C. A., Stendell-Hollis, N. R., Rock, C. L., Cussler, E. C., Flatt, S. W., and Pierce, J. P. Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer. LaRowe, T. L., Mares, J. A European multicentre, placebo-controlled supplementation study with alpha-tocopherol, carotene-rich palm oil, lutein or lycopene: analysis of serum responses. View abstract. Aside from protecting eyes, lutein uses also include helping prevent skin disorders, several types of cancer including colon or breast cancer, type 2 diabetes, and risk factors associated with coronary heart disease. Steinmetz KA, Potter JD. View abstract. Manzoni P, Guardione R, Bonetti P, et al. View abstract. Med.Sci.Sports Exerc. Chew EY, Clemons TE, Agrn E, et al. 2014 Jan;252(1):63-70. Photochem.Photobiol. Snellen, E. L., Verbeek, A. L., Van Den Hoogen, G. W., Cruysberg, J. R., and Hoyng, C. B. Neovascular age-related macular degeneration and its relationship to antioxidant intake. Plasma kinetics of lutein, zeaxanthin, and 3-dehydro-lutein after multiple oral doses of a lutein supplement. View abstract. Lutein protects the eyes by filtering out a percentage of damaging short-wavelength UV light that negatively affects delicate parts of the eyes, such asthe retina (the macula). 2000;71(3):239-245. 2003;94(1):57-63. View abstract. View abstract. Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer. 2002;76(3):595-603. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. An ancillary study of the women's health initiative. Broekmans, W. M., Berendschot, T. T., Klopping-Ketelaars, I. Eye Disease Case-Control Study Group. 2001;42(1):235-240. Lai JS, Veetil VO, Lanca C, et al. 2013 Jan;30(1):25-32. Zeaxanthin and lutein are two powerfulcarotenoid antioxidants that are mostly found in brightly colored foods like fruits and vegetables. Wright, A. J., Hughes, D. A., Bailey, A. L., and Southon, S. Beta-carotene and lycopene, but not lutein, supplementation changes the plasma fatty acid profile of healthy male non-smokers. Dorgan, J. F., Boakye, N. A., Fears, T. R., Schleicher, R. L., Helsel, W., Anderson, C., Robinson, J., Guin, J. D., Lessin, S., Ratnasinghe, L. D., and Tangrea, J. It is certified by the National Eczema Association, meaning it is safe for those with eczema or sensitive skina testament to its mildness. Front Aging Neurosci 2017;9:254. 2006;47(12):5227-5233. View abstract. A. Bloomer RJ, Fry A, Schilling B, Chiu L, et al. Bates, C. J., Chen, S. J., Macdonald, A., and Holden, R. Quantitation of vitamin E and a carotenoid pigment in cataractous human lenses, and the effect of a dietary supplement. Cho, E., Hankinson, S. E., Rosner, B., Willett, W. C., and Colditz, G. A. View abstract. Loughman J, Loskutova E, Butler JS, Siah WF, O'Brien C. Macular pigment response to lutein, zeaxanthin, and meso-zeaxanthin supplementation in open-angle glaucoma: A randomized controlled trial. 1996;66(4):316-321. B., Russell, R. M., and Yeum, K. J. Supplementation with lutein or lutein plus green tea extracts does not change oxidative stress in adequately nourished older adults. 2012;25(5):523-527. Taking care of sensitive skin is the first step in treating View abstract. View abstract. J Am Optom Assoc 1999;70:39-47. WebIf your eczema ( atopic dermatitis) flare-ups are really bad, oral corticosteroids are one of the treatment options that can help soothe your irritated skin. View abstract. Molecules. View abstract. Am J Epidemiol 1999;149:801-9. 2011;82(11):667-680. Are supplements really necessary to achieve benefits? Hu, F., Wang, Yi B., Zhang, W., Liang, J., Lin, C., Li, D., Wang, F., Pang, D., and Zhao, Y. Carotenoids and breast cancer risk: a meta-analysis and meta-regression. WebShop 12 Hour Mucus Relief DM Extended-Release Tablets Maximum Strength and read reviews at Walgreens. Br.J.Nutr. Kobayashi J, Tominaga E, Ozeki M, Okubo T, Nakagawa K, Miyazawa T. Randomized controlled trial of a water-soluble formulation of lutein in humans. View abstract. Acta Ophthalmol. 2008;87(6):1837-1843. View abstract. Gartner, C., Stahl, W., and Sies, H. Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human. Read Next: Top 7 Ways Carrot & Carrot Juice Benefit Your Body. View abstract. Saxena, S., Srivastava, P., and Khanna, V. K. Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. Bartlett, H., Howells, O., and Eperjesi, F. The role of macular pigment assessment in clinical practice: a review. Clin.Exp.Optom. This is why we need antioxidants to help neutralize free radicals. View abstract. The first 200 years. Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. A European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study. View abstract. Aleman, T. S., Duncan, J. L., Bieber, M. L., De Castro, E., Marks, D. A., Gardner, L. M., Steinberg, J. D., Cideciyan, A. V., Maguire, M. G., and Jacobson, S. G. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. View abstract. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Carotenoids and colon cancer. View abstract. View abstract. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. According to the Centers for Disease Control and Prevention (CDC), Americans get American Macular Degeneration Association, Top 7 Ways Carrot & Carrot Juice Benefit Your Body, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, Is Lamb Healthy? Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. View abstract. Novel phytonutrient contributors to antioxidant protection against cardiovascular disease. Spraycar M, ed. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. J Nutr 2006;136(5):1161-1165. View abstract. Central retinal thickness is positively correlated with macular pigment optical density. 5 Reasons to Add Lamb Meat to Your Diet, St. Johns Wort Benefits for Depression, PMS & Menopause. View abstract. The same goes for eating foods that naturally contain this carotenoid try pairing things like squash, carrots or eggs with healthy sources of fats, including nuts, coconut, olive oil or avocado, to boost their effectiveness. Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A. Arch.Ophthalmol. View abstract. Kang T, Liu Y, Chen X, et al. Circulation 6-19-2001;103(24):2922-2927. Note that the numbers in parentheses (1, 2, etc.) Dreher, M. L. Pistachio nuts: composition and potential health benefits. Relationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer. View abstract. Changes in plasma amino acid patterns in chronic alcoholic patients during ethanol withdrawal syndrome: their clinical implications. View abstract. View abstract. View abstract. Garcia-Closas, R., Agudo, A., Gonzalez, C. A., and Riboli, E. Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona, Spain. View abstract. Nutr Res 2001;21:797-809. Juturu V, Bowman JP, Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin Cosmet Investig Dermatol 2016;9:325-332. View abstract. Macular yellow pigment. Liu R, Wang T, Zhang B, et al. View abstract. Johnson, E. J., Chung, H. Y., Caldarella, S. M., and Snodderly, D. M. The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. Sadly, the incidence of AMD is expected to triple by 2025, according to the American Optometric Association. Curran-Celentano, J., Hammond, B. R., Jr., Ciulla, T. A., Cooper, D. A., Pratt, L. M., and Danis, R. B. Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Ma, L., Dou, H. L., Huang, Y. M., Lu, X. R., Xu, X. R., Qian, F., Zou, Z. Y., Pang, H. L., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., and Lin, X. M. Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. People who dont eat many vegetable or fruits can probably benefit from supplementing with higher doses, as can older adults, smokers and post-menopausal women. Invest Ophthalmol.Vis.Sci. Brown L, Rimm EB, Seddon JM, et al. Acta Ophthalmol. 2013;54(3):1781-1788. View abstract. View abstract. While we dont know exactly how lutein and cancer formation is tied just yet, correlational studies have shown that adults with higher levels of lutein in the blood experience a reduced risk of developing several forms of common cancers. Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study. View abstract. 10-10-2003;2:12. JAMA 1994;272:1413-20. Wang X, Jiang C, Zhang Y, et al. 2014;42(1):25-38. J Nutr 2004;134:1887-93. Lutein /zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. Br J Nutr 2021;126(7):1028-1039. Dwyer, J. H., Paul-Labrador, M. J., Fan, J., Shircore, A. M., Merz, C. N., and Dwyer, K. M. Progression of carotid intima-media thickness and plasma antioxidants: the Los Angeles Atherosclerosis Study. Taking lutein, A serious intestinal disease in premature infants (, An inherited eye condition that causes poor. Association of blood antioxidants and vitamins with risk of age-related cataract: a meta-analysis of observational studies. View abstract. 2009;40(6):1047-1054. Asia Pac J Clin Nutr 2017;26(3):406-11. The highest amount of dietary lutein is found in leafy green vegetables, such as: kale spinach broccoli lettuce parsley basil leeks peas Lutein can also be found in other Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. View abstract. Takeda, S., Masuda, Y., Usuda, M., Marushima, R., Ueji, T., Hasegawa, M., and Maruyama, C. Effects of mayonnaise on postprandial serum lutein/zeaxanthin and beta-carotene concentrations in humans. J Lab Clin Med 1999;134(6):592-598. J Clin Med 2019;8(1):77. View abstract. Nutrients. View abstract. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Ophthalmology 2001;108(11):1992-1998. Am J Clin Nutr 2005;82:88-97. View abstract. A case-control study. View abstract. Am.J.Clin.Nutr. View abstract. Wilson LM, Tharmarajah S, Jia Y, Semba RD, Schaumberg DA, Robinson KA. 1996;36(13):2001-2012. A., Klein, M. L., Gehrs, K. M., Johnson, E. J., Snodderly, D. M., Wallace, R. B., Chappell, R. J., Parekh, N., Ritenbaugh, C., and Mares, J. View abstract. Br.J Nutr 1999;82(3):203-212. Natarajan, L., Rock, C. L., Major, J. M., Thomson, C. A., Caan, B. J., Flatt, S. W., Chilton, J. Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case-control study. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. View abstract. Nutrients 2017;9(11):1246. 2012;53(10):6178-6186. Thurnham, D. I., Northrop-Clewes, C. A., Paracha, P. I., and McLoone, U. J. Ren YB, Qi YX, Su XJ, Luan HQ, Sun Q. B., Jenkins, L., and Mahomed, K. Plasma carotenoids, retinol, tocopherols, and lipoproteins in preeclamptic and normotensive pregnant Zimbabwean women. Invest Ophthalmol.Vis.Sci. Romagnoli, C., Giannantonio, C., Cota, F., Papacci, P., Vento, G., Valente, E., Purcaro, V., and Costa, S. A prospective, randomized, double blind study comparing lutein to placebo for reducing occurrence and severity of retinopathy of prematurity. Dagnelie G, Zorge IS, McDonald TM. Dherani, M., Murthy, G. V., Gupta, S. K., Young, I. S., Maraini, G., Camparini, M., Price, G. M., John, N., Chakravarthy, U., and Fletcher, A. E. Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population. Yagi, A., Fujimoto, K., Michihiro, K., Goh, B., Tsi, D., and Nagai, H. The effect of lutein supplementation on visual fatigue: a psychophysiological analysis. Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. 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