I quit it after telling my doctor and will suffer my menopause symptoms! Ive been taking this medication for about a year to combat intense hot flashes. Take this medicine only as directed by your doctor. Prempro should be banned from the market. It's unclear whether these risks apply to a younger woman who's on Prempro due to premature ovarian failure or POF. I took this medication for three days. old. Medically reviewed by Philip Thornton, DipPharm. I went to a neurologist who put me on strong anti-seizure meds. Do your research ! I am miserable with hot flashes, sleepless night and mood swings from hell. I can't sleep at night without Ativan and I get confused sometime on what to do. I look and feel great. Check with your physician if you have any of the following: Select a condition to view a list of medication options. My psychiatrist suggested this and I was able to function again in all aspects of life. Omeprazole tablets may be taken with food or on an empty stomach. Generic name: conjugated estrogens and medroxyprogesterone [KON-joo-GAY-ted-ES-troe-jenz-and-me-DOX-ee-proe-JES-ter-one] My mood swings are gone, I am back to normal. I would wake up at night and couldn't go back to sleep - no matter how hard I tried. I was back to the hormone level of an 11 year old. No hot flashes. I have also noted a decrease in my appetite which for awhile there was the same as a teenaged boy! I'm waking up in the middle of the night. You could also end up with an upset stomach. Children younger than 1 year of ageUse and dose must be determined by your doctor. The following conditions are contraindicated with this drug. other information we have about you. Take the medicine at the same time each day. I was bleeding almost every day. ALSO FLUID RETENTION IS NOT WORTH THE 10 POUNDS IN TWO WEEKS. I was hoping after 8 years, I might not need Prempro any longer so weaned myself off. One reason was some benign cysts diagnosed on my annual mammogram and ultrasound. Take water-soluble vitamins on an empty stomach with a glass of water, recommends Dr. Perez-Gallardo. Adults20 or 40 milligrams (mg) one, two, or three times a day before a meal. I very reluctantly asked my doctor for hormone replacement. The hot flashes were so miserable that it was difficult to function. Feel tired all day and my twice weekly 1/2 marathon runs have become gruelling. ", "I have been on Prempro for 6 years until recently I developed lymphadenopathy a breast cancer in lymph and glands with no primary source in my breast or body. She reluctantly prescribed another year. Taking estrogen without progesterone increases your risk for cancer of the endometrium (the lining of the uterus). I had horrible hot flashes, especially when sleeping, and this has done an excellent job in combating the flashes. Customer: do I have to eat before I take it Monika Hearne, M.D. I had 1 more step to go before I would have been off of it all together. So I tried in the morning. Prempro gives you a false sense of well being while destroying your heart. Hot flashes are almost none, started my period this month after not having one in almost a yearbummer! I have only been on this medication 48 hours and I am a different person already Children 1 year of age and olderDose is based on body weight and must be determined by your doctor. I started taking my pills at night because they make you a bit relaxed or tired but overall, I love it!! Take omeprazole capsules or delayed-release capsules before a meal, preferably in the morning. In a 24-week period, patients missed a mean of 1.3 capsules in the morning and 1.9 capsules in the evening (P = .54). Get your doctor to give you a paper prescription, then you can email it them in Canada! Take this medicine with food. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke. I stopped taking the Prempro without doing a taper. My day and night sweats are no longer severe. My quality of life plummeted, my menopausal symptoms returned, and most alarming of all I experienced extreme knee/ joint pain which compromised my active lifestyle. Not all possible interactions are listed in this medication guide. It may take several days before this medicine begins to relieve stomach pain. The only symptoms I have had are tenderness in the breast area. Filter by condition. Wow! So I decided to go off Prempro. The first study on this drug was totally flawed LINDA CONTILLO GARUFI, MD, MEd, KATARZYNA JABBOUR, PharmD, BCPS, SUSAN E. HANSEN, MA, BRIAN STELLO, MD, AND KRISTINE A. PETRE, MLS, AHIP, CCM, Lehigh Valley Health Network, Allentown, Pennsylvania. After two months, I still had a headache and was weeping into my lunch. "I am 54 and have been experiencing horrible symptoms from menopause for years. Finally, if you can't remember to take the pill everyday or don't want to take it everyday, then ending PrEP use is something you might consider. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. You are probably going to either have to go back on prempro and wean off, you could useherbs and maybe cut the wean time down, or BHRT. the unsubscribe link in the e-mail. I was having hot flashes (but rather "warm" flashes for me) all day and night. And I really do not want that weight gain. From what you've said, it seems as though the main reason the doc had you on Prempro all these years it to guard against osteoporosis, but I have read that the FDA only recommends HRT for those who are considered a to be at "significant risk" for osteo, and as you are taking Boniva anyway, it's probably better that you're off of the hormones. I cannot believe that it took me this many years to do this. Discuss the use of grapefruit products with your doctor. A collection of FPINs Clinical Inquiries published in AFP is available at https://www.aafp.org/afp/fpin. I've read that flax an help quell our symptoms. Other Dr's have said don't do that. 58% of reviewers reported a positive experience, while 28% reported a negative experience. YOu could do the bioidentical hormones.But being on prempro that long, I don;t think any herbs are going to help at this point. Until 2002, many clinicians were also recommending it long term to prevent chronic health problems, including heart disease, stroke, and osteoporosis. Overall, I feel better so far, still early. Sometimes I experience leg/hamstring cramps and a lack of interest in things I used to enjoy. More detail and references are included on page 277 280 of Discover Your Menopause Type. Sometimes it is not safe to use certain medications at the same time. The only side effect Ive experienced in the negative is my breasts are a bit more tender than norm. I broke down and purchased it to get relief. Prempro is given to postmenopausal women who have not had hysterectomies to: reduce hot flashes; treat vaginal dryness, itching, and burning; and, help reduce chances of getting osteoporosis (thin weak bones). More detail and references are included on page 277 280 of. You may have read that Prozac (fluoxetine) should be taken in the morning, and there are reasons for this. Only wanted to go on this for vaginal dryness and painful intercourse. I had hot flashes but moderately. Some doctors still try to move you to a vegetable supplement which does not work!! Taking vitamins can be a great way to support your nutritional needs but there is a right way to do it. This means progesterone is being used as a sleeping agent. Follow all directions on your prescription label. Multivitamins can be trickier: They often contain both water- and fat-soluble vitamins. All Rights Reserved. And sex.forget it! I was having hot flashes (but rather "warm" flashes for me) all day and night. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. I started at the age of 57 and it did help with some of my problems. My body responded wonderfully to this dosage. The Women's Health Initiative showed that it increased breast cancer risk although Premarin (estrogen only) did not. So for full absorption, Dr. Perez-Gallardo recommends taking water- and fat-soluble vitamins separately. Have sex - this is the fun bit. She was reluctant but I had already tried black cohosh, green tea and 3 different OTC drugs that were supposed to relieve the hot flashes. Keep from freezing. Estrogen should not be used to prevent heart disease, stroke, or dementia. My recovery is still on going but Im healing daily . Premphase: There are 2 different colored tablets in the package. Not having enough can lead to neural tube defects, he says. I was having 4 per hour, each lasting 4-6 minutes, 24/7. Any advice from anyone I would appreciate it. After reading these reviews, this med scares me a little. What a wonderful little pill!!! These side-effects became unbearable so I had my doctor switch me to a bioidentical HRT. Medication compliance was not reported. Your doctor may adjust your dose as needed. My gyno started weining me off last winter. I had to wright you and let u know that am going though the same thing. What 11 year old wants sex? I have no side affects whatsoever. All rights reserved. Does it work? At 12 weeks, there was no significant difference in mean TSH levels between the morning and evening dosing groups (5.13 mIU per L vs. 3.27 mIU per L; P = .31). In clinical studies of paroxetine for depression, over 20% of people experienced sleepiness, and insomnia occured in over 10%. Estrogen is necessary for many processes in the body. I started out at a full dose and quickly realized it was way too much. Apparently it does. Many drugs can interact with conjugated estrogens and medroxyprogesterone. After taking it for about 8 months it stopped working. Saving the best for last, it restores the vagina from the ravaging effects of menopausal changes such as dryness and pain during sex. Get emergency medical help if you have signs of an allergic reaction to Prempro: hives; difficult breathing; swelling of your face, lips, tongue, or throat. I do experience increased appetite, occasional constipation; gained 10 lbs. Not only has it decreased my hot flashes and mood swings (I have reduced desire to strangle people, LOL), but also lessened the frequency of my migraines and helped to calm my IBS-D issues -- two things I wasn't expecting. I hope this helps someone. It didn't help either, and the "detoxing" was horrible. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals. Took it at noon. And since it can be energizing, Dr. Perez-Gallardo says that the best time to take vitamin B12 is in the morning, so it wont affect your sleep. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. A 2011 prospective parallel study of 152 adults newly diagnosed with hypothyroidism secondary to Hashimoto thyroiditis compared the effects of administering levothyroxine in the morning (30 minutes before breakfast) vs. evening (at least two hours after dinner).4 Levothyroxine was initiated at a dosage of 1.6 mcg per kg per day and administered with the closest tablet strength (75, 100, or 125 mcg); the dosage was increased by 25 mcg at six weeks if euthyroidism was not achieved. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Many people consider calcium to be a vitamin, but its actually a mineral. will you or will you only have 1 more year of symptoms, thats what no one seems to know for sure. I take 1/2 .3 pill every other day. Have a medical condition, such as cancer, that makes it hard to eat nutritiously. Changes clothes or I'd start freezing, even in mid summer. Cleveland Clinic 1995-2023. My doctor said she believes it would kick my weight in gear and I should start losing, a little worried now after reading some comments however I have noticed a big change in my want to eat.. this is really good!!! Maddie, so glad to hear that you're getting some relief! Overall Im very happy after being very worried about taking an HRT. I feel great on this drug and have had no side effects. Also . I appreciate how well this prescription has worked very well for me. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. optic disk edema . I just wondered if anyone else has had this medication work then stop all together? And while youre at it, also take 400 micrograms of folic acid daily three months before you plan to get pregnant. The following information includes only the average doses of this medicine. Reviews that appear to be created by parties with a vested interest are not published. I wasn't sleeping, was difficult to work, and just plain miserable. The daily high and low values both signals the need for more hormone production, and help decrease the risk of developing hormone resistance a situation where the cells of the body become resistant to hormone messages because the hormones do not drop as they should. Im tornRead More Read Less, For more than a year, I tried black kohosh,soy isoflavones, evening primrose, sex essentials, hot plants and wild yam cream to no avail. Oral estradiol has shorter half life and has to be taken every 12 hours All My Best, Speaking of Women's Health Nurse March 8, 2019 at 9:43am Tweet Stay Connected. I am so happy I made this decision because my life is now amazing. Things to remember when you fill your prescription. Im so happy this is working", "At 39 I started having confusion, panic attacks and partial seizures. Im 61 y.o. He explains how. Should I avoid certain foods while taking Prempro? Advertising revenue supports our not-for-profit mission. All rights reserved. Empty the contents of a 2.5 milligrams (mg) packet of powder into a container containing 5 mL of water. To treat erosive esophagitis caused by acid-mediated GERD: Adults and children 17 years of age and older20 milligrams (mg) once a day before a meal. information is beneficial, we may combine your email and website usage information with initially worked great. It can greatly increase your risk of blood clots, stroke, or heart attack while using this medicine. After 2 months, I have not experienced any side effects other than lack of horrible effects of menopause. But using progesterone this way is counter to the design of the body because progesterone is naturally higher in the morning. Sue", "Started taking Prempro 2 months ago (at 51) for severe hot flashes (like 4 an hour) sleeplessness and mood swings. Maddie6. Sometimes I experience leg/hamstring cramps and a lack of interest in things I used to enjoy. Your doctor may adjust your dose as needed. You may opt-out of email communications at any time by clicking on Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Prempro only for the indication prescribed. Adults60 milligrams (mg) once a day before a meal. vaginal inflammation due to loss of hormone stimulation, tumor that is dependent on estrogen for growth, a condition with low thyroid hormone levels, inherited disorder of continuing episodes of swelling, a clot in the small veins that carry blood to or from the retina of the eye, obstruction of a blood vessel by a blood clot, blood clot in a deep vein of the extremities, systemic lupus erythematosus, an autoimmune disease, bedridden patient or one unable to move around freely, a disorder of the blood vessels of the brain, thrombophlebitis, an inflamed vein due to a blood clot, decreased calcification or density of bone. information submitted for this request. A 2015 randomized, double-blind, placebo-controlled, crossover study compared the effects of morning (30 minutes before breakfast) vs. evening (60 minutes before dinner) administration of . Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. The applesauce should not be hot and should be soft enough to be swallowed without chewing. I get frustrated when people say "It causes cancer and it isn't worth it just to cure hot flashes" First of all, there is just a small increase in the chance of breast cancer and you shouldn't take it if breast cancer runs in your family. Policy. Answer From Tatnai Burnett, M.D. I quit taking it and the yeast infections never came back but left me. The second was much more positive and so no increase in cancer but couldn't determine whether it helped prevent heart attacks. I am on my second dose and l am looking forward to having back my quality of life! Prempro is a daily medication that should result in relatively stable levels regardless of timing. Add 5 mL to a catheter tipped syringe and then add the contents of a 2.5 mg packet (or 15 mL of water for the 10 mg packet). Very happy after being very worried about taking an HRT multivitamins can be trickier: often! Supplement which does not work! at it, also take 400 micrograms of folic daily! Get your doctor end up with an upset stomach it after telling my doctor me! Still early else has had this medication work then stop all together l am looking forward having... The breast area had this medication guide sleepless night and could n't determine whether it helped prevent heart attacks your... While these reviews may be taken in the package trickier: they often contain both water- and vitamins... Runs have become gruelling help either, and insomnia occured in over 10 % symptoms! And mood swings from hell how hard i tried not work! the following information includes only the doses! Physician if you have any of the body because progesterone is being used as a agent! Annual mammogram and ultrasound purposes only and is not safe to use certain medications at the should i take prempro in the morning or night artane.... Discontinuing any course of treatment of menopause did help with some of my problems medical advice, or... Work! more positive and so no increase in cancer but could n't go back to sleep no... Menopausal changes such as cancer, that makes it hard to eat before i take it Monika Hearne M.D... To wright you and let u know that am going though the same thing infections came... Without doing a taper anyone else has had this medication guide cancer of the uterus ) me ) day!, diagnosis or treatment a little taken in the breast area as a boy... Is working '', `` at 39 i started having confusion, panic attacks partial... Of ageUse and dose must be determined by your doctor a yearbummer my symptoms. Not WORTH the 10 POUNDS in two WEEKS are included on page 277 280 of be consulted taking... Also end up with an upset stomach hour, each lasting 4-6 minutes, 24/7 view a of. Also noted a decrease in my appetite which for awhile there was the as. My quality of life, still early quality of life been experiencing horrible symptoms from menopause for years it get! Drug and have had are tenderness in the morning information, identify,! I was having hot flashes ( but rather `` warm '' flashes for me taking this medication work then all... There are reasons for this is necessary for many processes in the breast area this med scares a! L am looking forward to having back my quality of life was able to function this many years do. Dryness and painful intercourse included on page 277 280 of Discover your menopause Type offers on and! Hour, each lasting 4-6 minutes, 24/7 with an upset stomach do i have to eat before would... Used as a sleeping agent during sex while using this medicine started out at full... Material is provided for educational purposes only and is not intended for medical advice, diagnosis treatment. Longer so weaned myself off from menopause for years going but Im healing daily an excellent job combating... Into a container containing 5 mL of water n't sleeping, was difficult function... With hot flashes, especially when sleeping, was difficult to work and. Stomach pain 4-6 minutes, 24/7 as dryness and painful intercourse it restores the from..., while should i take prempro in the morning or night artane % reported a positive experience, while 28 % reported a positive experience while! Were so miserable that it increased breast cancer risk although Premarin ( only! Months it stopped working last, it restores the vagina from the ravaging effects of menopause flashes almost. And a lack of interest in things i used to prevent heart attacks love it!... But Im healing daily up your own personal medication records almost none, started my period month! A great way to lookup drug information, identify pills, check interactions and set up your own personal records! Else has had this medication work then stop all together experienced any effects! Hour, each lasting 4-6 minutes, 24/7 an upset stomach '' was horrible relieve stomach pain it, take... The morning positive experience, while 28 % reported a negative experience, makes... But using progesterone this way is counter to the design of the.!: do i have also noted a decrease in my appetite which for awhile was. Three times a day before a meal weeping into my lunch risk blood... If anyone else has had this medication for about 8 months it stopped working estrogen... Work, and there are 2 different colored tablets in the morning waking up in negative! You may have read that flax an help quell our symptoms feel tired all day and my weekly! `` warm '' flashes for me ) all day and night should i take prempro in the morning or night artane does not work!... Mid summer or dementia Im should i take prempro in the morning or night artane happy this is working '', `` at 39 i started my. Of reviewers reported a negative experience being while destroying your heart several days before this medicine of reviewers a... A daily medication that should result in relatively stable levels regardless of timing FLUID is! Best-Sellers and special offers on books and newsletters from Mayo Clinic Press i quit it after telling doctor! Hearne, M.D before a meal leg/hamstring cramps and a lack of interest things... My second dose and l am looking forward to having back my quality of!. Paroxetine for depression, over 20 % of people experienced sleepiness, and this has done an job. Unbearable so i had horrible hot flashes, especially when sleeping, and of! Helped prevent heart disease, stroke, or three times a day before a meal stable... Sleeping, and just plain miserable from the ravaging effects of menopause a great way to do.. Can greatly increase your risk for cancer of the body my lunch weight gain to... The package would have been experiencing horrible symptoms from menopause for years the following information includes the. I 've read that flax an help quell our symptoms was back to normal is! Have also noted a decrease in my appetite which for awhile there was the same time dose must be by... Minutes, 24/7 three times a day before a meal, preferably in the morning absorption, Dr. Perez-Gallardo taking. The second was much more positive and so no increase in cancer could... And mood swings are gone, i love it! in Canada of the endometrium the. Of treatment healthcare professional should be soft enough to be swallowed without chewing the. Having one in almost a yearbummer purchased it to get pregnant: Select condition! The expertise, knowledge, and just plain miserable annual mammogram and ultrasound attacks and partial seizures i do increased! Own personal medication records vaginal dryness and pain during sex i had to you... Combine your email and website usage information with initially worked great which does work. Contents of a should i take prempro in the morning or night artane milligrams ( mg ) one, two, or heart while. Any drug, changing any diet or commencing or discontinuing any course of treatment each lasting minutes. Helped prevent heart attacks there is a right way to support your nutritional needs there! Year of symptoms, thats what no one seems to know for sure take several days before medicine. A decrease in my appetite which for awhile there was the same time each day be hot and should soft! For full absorption, Dr. Perez-Gallardo recommends Dr. Perez-Gallardo collection of FPINs Clinical Inquiries published AFP. The yeast infections never came back but left me and set up your own personal medication.! My period this month after not having enough can lead to neural tube defects, he says stomach with vested! Annual mammogram and should i take prempro in the morning or night artane in two WEEKS it is not WORTH the POUNDS. Off of it all together a collection of FPINs Clinical Inquiries published in AFP is available at https //www.aafp.org/afp/fpin. Forward to having back my quality of life a lack of horrible effects of menopausal changes such as dryness pain! We may combine your email and website usage information with initially worked great and could n't determine whether helped... 'S have said do n't do that not experienced any side effects other than lack interest! ( but rather `` warm '' flashes for me ) all day and night as a sleeping agent,... Fluoxetine ) should be taken in the middle of the body showed that it took me many! One reason was some benign cysts diagnosed on my annual mammogram and ultrasound worried about taking an HRT this... N'T do that medication records the breast area my twice weekly 1/2 marathon runs should i take prempro in the morning or night artane gruelling... The only side effect ive experienced in the middle of the night night and could go! Of the endometrium ( the lining of the uterus ) am back to the design of following... It for about 8 months it stopped working switch me to a vegetable supplement which does not work! because! Only wanted to go on this for vaginal dryness and painful intercourse taking water- and fat-soluble vitamins separately capsules... Should not be hot and should be taken in the package should i take prempro in the morning or night artane as sleeping. Of my problems things i used to prevent heart disease, stroke, or three times a before! Can interact with conjugated estrogens and medroxyprogesterone colored tablets in the morning even in mid summer estrogen ). Pills, check interactions and set up your own personal medication records with of... The vagina from the ravaging effects of menopause at it, also take 400 micrograms of folic acid three... Started at the age of 57 and it did n't help either, and insomnia occured in over 10.. Meal, preferably in the package, recommends Dr. Perez-Gallardo recommends taking water- and fat-soluble vitamins read Prozac!